ABSTRACT
The appearance of fake news in Ecuador, during the period of confinement generated by the pandemic related to COVID-19, evidenced the various dimensions of this phenomenon. This paper analyzes the spread of fake news about Covid in the Ecuadorian technological scene, in order to promote an understanding and subsequent debate that contributes to the generation of prevention strategies and even reduction of its impact on the Internet and social networks, for the benefit of communication and democracy. One of the serious problems caused by disinformation is the appearance of rumors, which in the context of a health emergency cause anguish and despair among the population. This is where a social environment is needed in which the State shields the production of fake news and the destruction of disinformation from official communication, through transparent and precise communication, with clear and detailed messages on the form of prevention and attention, that it arrives by truthful technological means. Much better if these are disseminated through official spokespersons from different professional branches: scientific community, authorities with responsibilities in health matters and civil society organizations with an aligned and coherent discursive line, to share certainties with the public and appease the anguish of the situation, and communication technology professionals. In the context of political information and technological strategic communication, it is worrying that social networks are the strategic field to attack the adversary by creating rumors that are spread as fake news. A similar case occurs with the false information that circulates on social networks in relation to the health emergency, and that puts people's lives at risk. As evidenced, information technology is a weapon on an unprecedented scale. This is precisely because the technological and communicational advances of the information society have facilitated the fabrication and manipulation of content that, when disseminated through social networks, dramatically amplifies the lies produced by the States, by populist politicians and by dishonest corporations, among the population, that lacks criteria to assess these technological contents. © 2023, The Author(s), under exclusive license to Springer Nature Switzerland AG.
ABSTRACT
As a consequence of the Covid-19 pandemic, the socialization of individuals and the training and professional development processes have been adapted through the use of information and communication technologies, in the educational field to continue with the teaching process - learning classes are held remotely so it is necessary to be connected to a device. In this sense, the present investigation focuses on anxiety and nomophobia, that is, the irrational fear of not connecting to a device. The objective of this study was to determine anxiety and nomophobia in virtual education students in the context of a pandemic. The research was basic, with an explanatory level, non -experimental, causal correlational design. The sampling was probabilistic-stratified. The population consisted of 275 students and the sample was 52 students. The survey was used as a technique and the instrument for the anxiety variable was a Trait-State Anxiety inventory which consisted of 40 items and considered the trait and state anxiety dimensions with 20 items each, and for the nomophobia variable the questionnaire was used. And nomophobia questionnaire (NMP-Q), which considered four dimensions. According to the results , p < 0.01 and R value = 0.713, which indicates a positive and high correlation between both variables. Concluding that there is a significant relationship between the anxiety and nomophobia variables in virtual education students in the context of a pandemic.
ABSTRACT
Due to the remote classes as a result of the pandemic, it became evident the increase in the use of cell phones in students, this brought with it alterations in the behavior of students and psychological consequences such as the development of stress, anxiety, depression, among others. However, these effects do not develop to the same extent in all individuals since factors such as personality influence them. Thus, the present study aimed to determine the relationship between personality and nomophobia in virtual education students in the context of the pandemic. The research was of basic type, with an explanatory level, non-experimental, causal correlational design. The population was 328 students and the sample consisted of 104 students. The instruments used were: the nomophobia questionnaire NMP-Q (20 items) and the Eysenck personality inventory (49 items). According to the results obtained, the relationship index between personality and nomophobia is 0.815, and there is a significance of 0.000, which is less than 0.05, so the null hypothesis is rejected, concluding that personality and nomophobia are related in a high significant way.
ABSTRACT
The appearance of fake news in Ecuador, during the period of confinement generated by the pandemic related to COVID-19, evidenced the various dimensions of this phenomenon. This paper analyzes the spread of fake news about Covid in the Ecuadorian technological scene, in order to promote an understanding and subsequent debate that contributes to the generation of prevention strategies and even reduction of its impact on the Internet and social networks, for the benefit of communication and democracy. One of the serious problems caused by disinformation is the appearance of rumors, which in the context of a health emergency cause anguish and despair among the population. This is where a social environment is needed in which the State shields the production of fake news and the destruction of disinformation from official communication, through transparent and precise communication, with clear and detailed messages on the form of prevention and attention, that it arrives by truthful technological means. Much better if these are disseminated through official spokespersons from different professional branches: scientific community, authorities with responsibilities in health matters and civil society organizations with an aligned and coherent discursive line, to share certainties with the public and appease the anguish of the situation, and communication technology professionals. In the context of political information and technological strategic communication, it is worrying that social networks are the strategic field to attack the adversary by creating rumors that are spread as fake news. A similar case occurs with the false information that circulates on social networks in relation to the health emergency, and that puts people’s lives at risk. As evidenced, information technology is a weapon on an unprecedented scale. This is precisely because the technological and communicational advances of the information society have facilitated the fabrication and manipulation of content that, when disseminated through social networks, dramatically amplifies the lies produced by the States, by populist politicians and by dishonest corporations, among the population, that lacks criteria to assess these technological contents. © 2023, The Author(s), under exclusive license to Springer Nature Switzerland AG.
ABSTRACT
Background: The relevance of studying immune response after SARS-CoV-2 vaccination in patients with infammatory immune-mediated diseases (IMIDs) represents a deep concern regarding the risk estimation and management of patients with these diseases on immunomodulatory drugs. It is well known that certain treatments as anti CD20 therapies results in a diminished immunogenicity against common vaccines but it is a scarce data regarding the cellular protection obtained upon vaccination between patients with different IMID and between different treatments. Objectives: To compare a potential detriment on cellular and antibody-mediated protection upon SARS-CoV-2 vaccination in patients with IMIDs treated with immunosuppressive drugs. Methods: We recruited 73 patients with rheumatoid arthritis-RA-(n=49), spondy-larthritis-SpA-(n=19), infammatory bowel disease-IBD-(n=5), idiopathic juvenile arthritis-IJA-(n=2) and heterogenous group composed of sclerodermia, lupus, uveitis(n=6). They were treated mainly with rituximab (n=27), TNFi (n=37) or JAKi (n=3). We collected data of age,sex, csDMARDs, previous SARS-CoV-2 infection, last RTX infusion and prednisone use. After one month of vaccination, we assessed the humoral response performing the Thermo Scientific EliA SARS-CoV-2-Sp1 IgG Test (positivity cut-off >0.70 IU/ml) which was also compared with the data with of 35 healthy controls. In addition, in 40 patients who had serum antibody levels under 100UI/ml, we analysed the cellular response by the use of the QuantiFERON SARS-CoV-2 Starter Pack (Quiagen). A cut-off value of 0.15 IU/ml discriminate between positive or negative cell-mediated immune responses. We compared differences among the different IMIDs and between the different immu-nosuppressive treatments through non-parametric test (p<0.05) Results: Regarding demographic characteristics of patients, older patients (>56 years) and female sex were factors which were associated with low titles of serum antibodies. Anti-spike IgG antibodies were present in an 86% of the IMIDs patients and in 100% healthy controls with signifcant different IgG titre (median [IQR]): 51[11-184] vs 700[440-940];p<0.0001. The differences between (median [IQR]) serum antibody levels were statistically different between IMID type: 33[1-138] in RA vs 94[34-191] in SpA vs 204[187-204] in IBD vs 133[61-204] in IJA vs 13[1.5-31.8] in the rest;p=0.04. Remarkably, patients with IBD who had the highest antibodies titles were the youngest compared with the other patients. Target of the therapy played also an important role in serum antibody levels being these: 3.6 [0.7-51] in RTX patients vs 156 [45-204] in TNFi vs 40 [18-58] in JAKi patients;p<0.0001. In those patients who the last infusion of rituximab was, at least, one year before vaccination presented CD19+ B cells detected by fow cytometry and anti-spike IgG antibodies as well. Cell-mediated responses to SARS-CoV-2 were positive in 33% of IMIDs patients, indeterminated in 3% and negative in 65% of the patients. Strikingly, out of the 33% positive patients, 85% were treated with RTX. A 61% of the RTX patients had inducible cell-mediated responses vs 14% of the patients treated with TNFi;p<0.01. On the other hand, there were not differences in cell-mediated responses between positive and negative antibody patients. Conclusion: Titres of serum antibodies against spike protein of SARS-CoV-2 were lower in IMIDs patients than in controls. Patients with RTX had lower rates of positivity humoral response as well as lower serum titles than patients treated with other therapies regardless the patients 'age. Neverthless, in those patients in whom RTX infusion was delayed because of vaccination they conserved a humoral response. On the other hand, more patients treated with RTX had inducible cell-mediated responses compared with patients with TNFi.
ABSTRACT
The objective of this work is to propose the acquisition of data under free software for a crazyflie-type quadcopter as a tool for precise mathematical modeling in times of COVID 19. It was supported by authors who leveraged theoretical innovations on drones, modeling mathematical and telemetry respectively such as Nonami, Kenzo. et al. (2010), Barhart. et al. (2011) as well as Malaver et al (2016). The methodology was descriptive, not experimental - Field. The research had no population and sample, it was consolidated through an analysis unit that was conceived as the Quadcopter drone. Among the techniques and instruments, direct observation was used. As an instrument, the notebook was used as well as a free data acquisition software obtained by flight telemetry. The results of the investigation showed the characterization of the physical variables that this device possesses, which were vital to be able to make the pertinent modifications at the free software level in the data acquisition platform, thus proposing a patch for interconnection as well as free extraction. to multiple data platforms from flights.
ABSTRACT
Background: The COVID-19 pandemic evidenced the fragility of the agri-food sector by affecting the food supply chains which directly depend on the health of its main actors. In this context, countries need to rethink the agricultural production models, considering environmental and human health as priorities to achieve food safety. Aim: Systematically review the state of the art regarding the role of agricultural genetic resources as a source of resilience in the face of events such as the present pandemic as a point of reflection for the identification of opportunities for the restructuring of regional agriculture sensitive to nutrition for health. Methodology: Exhaustive search and analysis of documentary information regarding the effects of COVID-19 on the agri-food sector and the role of agricultural genetic resources in the current pandemic were conducted. Then, through an analysis of the occurrence and association of the main terms addressed in the literature considered, the thematic axes were drawn to address the central discussion of the systematic review. Results: Terms co-occurrence analysis corroborated the relevance and pertinence of the topic addressed. Additionally, the importance of the conservation of agricultural genetic resources and implementation of sustainable agriculture models, as a source of resilience to pandemics, was visualized. The discussion addressed the impact of the pandemic on the Mexican agri-food sector and the restructuring of post-COVID-19 agriculture through the nation and nutrition-sensitive agriculture for health approaches. Implications: The exhaustive analysis of the relationship COVID-19-agricultural genetic resources-health in Mexico highlights the need for the generation of agricultural policies and the increase in multidisciplinary research that favors biodiversity as a source of sustainability, productivity, and health for agroecosystems and the welfare of humanity. Conclusions: A fatalistic scenario for humanity seems to be dissipating in the face of the possibilities of rethinking the economic, social, and agricultural systems from the approaches of the nation and nutrition-sensitive agriculture for health, where, through the responsible use of agricultural resources it is possible to rebuild an agri-food production system with a tendency to resilience to events such as the current pandemic caused by the COVID-19 disease. © 2022 Universidad Autonoma de Yucatan. All rights reserved.
ABSTRACT
With the emergence of targeted therapies, defining the best strategy for the treatment of previously untreated CLL patients remains challenging. The aim of this phase 2 study was to compare the efficacy of an association with ibrutinib and venetoclax (IV) to the standard FCR regimen in fit patients with intermediate-risk CLL defined by either unmutated IGHV status, 11q deletion, or complex karyotype in the absence of TP53 abnormality. Patients were randomized 1:1 between two treatment arms, i.e. FCR 6 cycles or IV. After a lead-in phase of ibrutinib as a single agent from the month (M)1 to M3, the total duration of treatment with IV was based on the response achieved at M9;if bone marrow (BM) MRD was <0.01% using flow cytometry, the treatment was continued for 6 additional months until M15 and then stopped;if BM MRD at M9 was ≥0.01%, the treatment with IV was continued for 18 additional months until M27. The primary endpoint was the percentage of patients with BM MRD <0.01% at M27 in both arms. We present here the preliminary results on the first evaluation done at M9 including CT-scan, BM biopsy, and MRD assessment in PB and BM after the inclusion of all the 120 patients as initially planned. One hundred and twenty patients were enrolled from September 2019 to February 2021. The median age was 59 [34-72] and 61 [34-74] years in the FCR and IV arms, respectively. The characteristics of the patients were well-balanced between the 2 arms in terms of gender (male 72% FCR, 74% IV), PS ECOG 0-1 (59% FCR, 68% IV), and Binet stage (A, B, and C 15, 64, 21% for FCR;8.5, 59, and 32% for IV). No major difference in terms of cytogenetic features was noted, all patients but one had unmutated IGHV. At the time of data cut-off for this interim analysis, the median follow-up for all cohort was 12.7 [4.5.9-21.4] months. The frequency of patients presenting all grades adverse events (AE) so far was 90% (grade ≥3: 45%) in the FCR arm and 80% (grade ≥3: 45%) in the IV arm. The rate of infusion-related reactions (IRR) in the FCR arm was 35% on cycle 1-day 1 (14% grade 3-4);for the IV arm, 5% of patients experienced tumor lysis syndrome (TLS) (grade 3 for 1 patient). Ibrutinib doses were reduced for seven patients (four permanently stopped and three resumed at a lower dose because of toxicities (digestive, hepatic, or hematological). Venetoclax was permanently discontinued before M9 in four patients (digestive toxicities and grade 4 neutropenia). Fifty-two serious adverse events were reported of which 22 were in the IV arm (among them one sudden death, one ischemic stroke, one acute coronary syndrome, two atrial fibrillations, two TLS, two acute renal failures, one hepatitis, one neutropenia, two COVID pneumonitis, and one osteoporotic fracture) and 30 in the FCR arm (among them five febrile neutropenia, one hemolytic anemia, one thrombocytopenia, three IRR, three TLS, three COVID pneumonitis, one acute myeloid leukemia, one myelodysplasic syndrome). All patients with COVID pneumonitis had a favorable evolution with the need for intensive care and convalescent plasma for three of them. The first 85 patients included in the study have reached M9 and among them, nine prematurely discontinued the study, (one active hemolysis, one ischemic stroke, one TLS, one hepatitis, and one sudden death in the IV arm;three hematologic toxicities and one early progression in the FCR arm). In the evaluated patients (n=74), 69% of patients in the FCR arm and 43% of patients in the IV arm achieved bone BM MRD <0.01%. The complete (CR, CRi) and partial response rates were 56 and 44% in the FCR arm and 74 and 26% in the IV arm, respectively. In conclusion, preliminary results show a lower BM MRD rate in the IV arm compared to the FCR arm at M9, with toxicity that remains significant and relatively similar between the two arms. However, BM MRD rate may improve after longer exposure to the IV combination and the analysis of the primary endpoint at M27 will be decisive in determining the best therapeutic strategy.
ABSTRACT
With the emergence of targeted therapies, defining the best strategy for the treatment of previously untreated CLL patients remains challenging. The aim of this phase 2 study was to compare the efficacy of an association with ibrutinib and venetoclax (IV) to the standard FCR regimen in fit patients with intermediate risk CLL defined by either unmutated IGHV status, 11q deletion or complex karyotype in the absence of TP53 abnormality. Patients were randomized 1:1 between two treatment arms, ie FCR 6 cycles or IV. After a lead-in phase of ibrutinib as a single agent from month (M)1 to M3, the total duration of treatment with IV was based on the response achieved at M9;if bone marrow (BM) MRD was < 0.01% using flow cytometry, the treatment was continued for 6 additional months until M15 and then stopped;if BM MRD at M9 was ≥ 0.01%, the treatment with IV was continued for 18 additional months until M27. The primary endpoint was the percentage of patients with BM MRD < 0.01% at M27 in both arms. We present here the preliminary results on the first evaluation done at M9 including CT-scan, BM biopsy and MRD assessment in PB and BM after the inclusion of all the 120 patients as initially planned. One hundred and twenty patients were enrolled from September 2019 to February 2021. The median age was 59 [34-72] and 61 [34-74] years in the FCR and IV arms, respectively. The characteristics of the patients were well balanced between the 2 arms in terms of gender (male 72% FCR, 74% IV), PS ECOG 0-1 (59% FCR, 68% IV) and Binet stage (A, B and C 15%, 64%, 21% for FCR;8.5%, 59% and 32% for IV). No major difference in terms of cytogenetic features was noted, all patients but one had unmutated IGHV. At the time of data cut-off for this interim analysis, the median follow-up for the all cohort was 11 [2.9 - 19.8] months. The frequency of all grades adverse events (AE) observed so far was 53% (grade 3-4, 24%) in the FCR arm and 47% (grade 3-4, 17%) in the IV arm. The rate of infusion-related reactions (IRR) in the FCR arm was 35% on cycle 1-day 1 (14% grade 3-4);for the IV arm, 6% of patients experienced tumor lysis syndrome (TLS) (grade 4 for 4 patients). ibrutinib doses were reduced for 7 patients (4 permanently stopped and 3 resumed at a lower dose because of toxicities (digestive, hepatic or haematological)). Venetoclax was permanently discontinued before M9 in 4 patients (digestive toxicities and grade 4 neutropenia). Forty serious adverse events were reported of which 15 in the IV arm (1 sudden death, 1 ischemic stroke, 2 atrial fibrillations, 2 clinical TLS, 1 hepatitis, 1 neutropenia, 4 COVID pneumonitis and one osteoporotic fracture) and 25 in the FCR arm (2 neutropenias, 1 anemia, 1 thrombocytopenia, 1 autoimmune haemolytic anemia, 3 IRR, 4 TLS, 2 COVID pneumonitis, 4 fever episodes of undetermined origin, 1 community-acquired pneumonia, 1 gastrointestinal toxicity, 1 confusion, 2 chest pains, 1 acute myeloid leukemia, 1 myelodysplasic syndrome). The patients with COVID pneumonitis had a favorable evolution with the need for intensive care and convalescent plasma for 3 of them. The first 60 patients included in the study have reached M9 and among them, 6 prematurely discontinued the study, 3 in each arm (active hemolysis, ischemic stroke and sudden death in the IV arm;2 grade 4 hematologic toxicities and 1 early progression in the FCR arm). In the evaluated patients (n=54), 71% of patients in the FCR arm and 48% of patients in the IV arm achieved bone BM MRD < 0.01%. The complete (CR, CRi) and partial response rates were 54% and 46% in the FCR arm and 76% and 24% in the IV arm respectively. In conclusion, the preliminary results show a lower BM MRD rate in the IV arm compared to the FCR arm at M9, with a toxicity that remains significant and relatively similar between the two arms. However, BM MRD rate should improve after longer exposure to the IV combination and the analysis of the primary endpoint at M27 will be decisive in determining the best therapeutic strategy. Disclosures: Quinquenel: Abbvie: Honoraria;Jansse : Honoraria;AstraZeneca: Honoraria. Laribi: Le Mans Hospital: Research Funding;Novartis: Other: Personal Fees, Research Funding;Takeda: Other: Personal Fees, Research Funding;BeiGene: Other: Personal Fees;IQONE: Other: Personal Fees;AbbVie: Other: Personal Fees, Research Funding;Astellas Phama, Inc.: Other: Personal Fees;AstraZeneca: Other: Personal Fees;Jansen: Research Funding. Cymbalista: Lilly-LOXO: Honoraria, Membership on an entity's Board of Directors or advisory committees;Janssen: Honoraria, Membership on an entity's Board of Directors or advisory committees;ASTRA ZENECA: Honoraria, Membership on an entity's Board of Directors or advisory committees;Abbvie: Honoraria, Membership on an entity's Board of Directors or advisory committees;Roche: Honoraria, Membership on an entity's Board of Directors or advisory committees. Leblond: AstraZeneca: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees;Lilly: Consultancy;AbbVie: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Other: Travel Support;Roche: Honoraria;Amgen: Honoraria;Beigene: Honoraria, Membership on an entity's Board of Directors or advisory committees;Janssen: Honoraria, Membership on an entity's Board of Directors or advisory committees. Dartigeas: Astra-Zeneca: Membership on an entity's Board of Directors or advisory committees, Other: travel grants/Congress;Abbvie: Membership on an entity's Board of Directors or advisory committees, Other: travel grants/Congress;Janssen: Membership on an entity's Board of Directors or advisory committees, Other: travel grants/Congress. Ferrant: Janssen: Other: Travel, Accommodations, Expenses;AbbVie: Honoraria, Other: Travel, Accommodations, Expenses;AstraZeneca: Honoraria. de Guibert: Janssen: Consultancy, Honoraria;AbbVie: Consultancy, Honoraria;Gilead: Consultancy, Honoraria. Feugier: Astrazeneca: Consultancy, Honoraria;Gilead: Consultancy, Honoraria;Abbvie: Consultancy, Honoraria;Amgen: Honoraria;Janssen: Consultancy, Honoraria. Cartron: Roche, Celgene-BMS: Consultancy;Danofi, Gilead, Novartis, Jansen, Roche, Celgene-BMS, Abbvie, Takeda: Honoraria. Ysebaert: Abbvie, AstraZeneca, Janssen, Roche: Other: Advisory Board, Research Funding.
ABSTRACT
An experience of intergenerational community training and participation is outlined involving students from the Faculty of Education in Soria and senior citizens. This intervention was carried out in the first four months of the 2020-21 academic year. The action research involves the use of the podcast as a tool for socio-educational innovation and communication between different groups of ages and training contexts. The aim is to foment relationships between both groups and encourage encounters within the context of Covid-19. It is hoped to stimulate closer contact, eliminate gerontophobic prejudices and enhance social health. The activity is based on the premise of lifelong education in formal, non-formal and informal contexts. The pandemic adds the emerging goal of alleviating involuntary isolation, particularly among more vulnerable elderly people. This is a comprehensive experience based on ethnographic fieldwork and focused on experimentation. It is concluded that this type of action research reduces social prejudice and the impact of the digital divide. Furthermore, despite the unfulfilled wishes to be present in person expressed by the participants (who experienced the screen both as a barrier and, too, facilitator of encounters), positive, healthy socioeconomic synergies were forged in both groups.
ABSTRACT
This paper provide an overview of the benefits that the integration of IoT and Blockchain can produce on the Humanitarian Aid Supply Chain (HASC). Consdering the large number of partner involved in HASC, traditional centralized information systems become very vulnerable. In the same sense, the lack of mutual knowledge obstruct the needed cooperation. The joint use of IoT and Blockchain can overcome these problems. Main benefit as well as barriers to this implementation is analyzed, considering the diferent phases of the HASC. © 2021 Publicaciones Dyna Sl. All rights reserved.
ABSTRACT
The COVID-19 outbreak has become a worldwide concern for everyone, and specifically for Higher Education Institutions, their students, teachers and those responsible for university public policies. Social distancing is now the primary consideration for any student when deciding where and how to study, reducing their willingness to educate themselves in physical settings with others who may carry the virus. In this context, this article analyzes how the Covid-19 pandemic affects Ecuadorian universities in the form of a communication and marketing trial, and its influence on university actors. The Covid-19 crisis has put the processes of social structures to the test. Communication and marketing are examples of these processes that face an unprecedented and unforeseen situation. In this sense, it is intended to reflect on how the pandemic affects and will condition the practice of university communication, both internal communication and its link with society. Finally, emphasis is placed on the importance of the universities assuming that reputation is a risk, and that this risk must be managed with the techniques and tools of communication, since the pandemic demonstrated higher education institutions the importance of managing relationships of trust with their teachers and students. © 2021, The Author(s), under exclusive license to Springer Nature Switzerland AG.